Preclinical Imaging

Research

Here are some select publications that serve as examples of the kind of research being performed at Preclinical Imaging:

1. Rousseau J, Wang TY, McClendon S, Ortega D, Orlando M, Beeman SC, Bartelle BB, Wang KC. Monocyte-Mimetic Contrast Agent Enables Targeted and Sensitive Magnetic Resonance Imaging of Atherosclerotic Lesions. Adv Healthc Mater. 2026 Jan;15(3):e02001. doi: 10.1002/adhm.202502001. Epub 2025 Sep 30. PMID: 41024730.
2. Elkoury E, Yehia A, Caparelli EC, Geda YE, Ortega D, Yamada N, Hakhu S, Beeman SC, Ross TJ, Yang Y, Zhou Y, Port JD, Abulseoud OA. Brain Volumetric Changes Post-COVID-19: A Systematic Review. Brain Sci. 2025 Nov 22;15(12):1255. doi: 10.3390/brainsci15121255. PMID: 41440051; PMCID: PMC12730699.
3. Son Y, Li P, Ortega D, Qiu H, Prachyl H, Yang M, Zhu W. Generation of a Human Induced Pluripotent Stem Cell Line Expressing a Magnetic Resonance Imaging Reporter Gene. Small Methods. 2024 Oct;8(10):e2301764. doi: 10.1002/smtd.202301764. Epub 2024 May 6. PMID: 38708688; PMCID: PMC11483194.
4. D.R. Griffiths, L.M. Law, C.Young,  A. Fuentes, S. Truran, N. Karamanova, L.C. Bell, G. Turner, H. Emerson, R. Gonzales, P.D. Reaven, C.C. Quarles, R.Q. Migrino, J. Lifshitz, Chronic Cognitive and Cerebrovascular Function Following Diffuse Mild to Moderate Traumatic Brain Injury in Rats. Journal of Neurotrauma, 2022, 39, 19-20.
5. K. Bhatia, A. Kindelin, M. Nadeem, M.B. Khan, J.X. Yin, A. Fuentes, G.H. Turner, M.C. Preul, A.S. Ahmad, E.J. Mufson, M.N. Hoda, M.F. Waters, S. Ahmad, A.F. Ducruet, Complement C3a receptor (C3aR) mediates vascular dysfunction, hippocampal pathology and cognitive impairment in a mouse model of VCID. Translational Stroke Research, 2022, 13, 816-829.
6. C. Han, M. Lang, C. Nguyen, E.L. Melendez, S. Mehta, G. Turner, M.T. Lawton, S.P. Oh, Novel Experimental Model of Brain Arteriovenous Malformations Using Conditional ALK1 Gene Deletion in Transgenic Mice. Journal of Neurosurgery, 2021, 137, 1, 163-174.
7. V.N. Bharadwaj, C. Copeland, E. Mathew, J. Newbern, T.R. Anderson, J. Lifshitz, V.D. Kodibagkar, S.E. Stabenfeldt, Sex dependent macromolecule and nanoparticle delivery in experimental brain injury. Tissue Engineering, 2020, 26,13-14, 688-701
8. S. Agarwal, P.K. Gulaka, U. Rastogi, V.D. Kodibagkar, More bullets for PISTOL: linear and cyclic siloxane reporter probes for quantitative 1H MR oximetry, Sci Rep., 2020, 10(1):1399
9. Vidya Shankar R, Kodibagkar VD*. A Faster PISTOL for 1H MR-based Quantitative Tissue Oximetry. NMR Biomed 2019. 32(5):e4076.
10. Su F, Agarwal S, Pan T, Qiao Y, Zhang L, Shi Z, Kong X, Shi Z, Day K, Chen M, Meldrum D*, Kodibagkar VD*, Tian Y*, Multifunctional PHPMA-derived polymers for pH sensing, fluorescence imaging and magnetic resonance imaging. ACS Appl Mater Interfaces. 2018 Jan 17;10(2):1556-1565. doi: 10.1021/acsami.7b15796
11. M. Chauhan, R.V. Shankar, N.A. Kumar, V.D. Kodibagkar, R. Sadleir, Multi-shot Echo-Planar MREIT for fast imaging of conductivity, current density and electric field distributions, Magnetic Resonance in Medicine, 2018, 79:71–82
12. E.M. Rutter, T.L. Stepien, B.J. Anderies, J.D. Placensia, E.C. Woolf, A.C. Scheck, G.H. Turner, Q. Liu, D. Frakes, V. Kodibagkar, Y. Kuang, M.C. Preul, E.J. Kostelich, Mathematical Analysis of Glioma Growth in a Murine Model, Scientifc Reports, 2017, May, 7(1):2508
13. N.L. Martirosyan, G.H. Turner, J.A. Kaufman, M.Y.S. Kalani, N. Theodore, M.C. Preul, Manganese Enhanced MRI Offers Correlation with Severity of Spinal Cord Injury of Experimental Models, The Open Neuroimaging Journal, The Open Neuroimaging Journal, 2016, Nov, 10(1):139-47
14. E.C. Woolf, K.L. Curley, Q. Liu, G.H. Turner, J.A. Charlton, M.C. Preul, A.C. Scheck, The ketogenic diet alters the hypoxic response and effects downstream processes involved in angiogenesis, invasion and vascular permeability in glioma, PLOS ONE, 2015, Jun, 10(6):e0130357
15. Addington C, Cusick A, Shankar RV, Agarwal S, Stabenfeldt SE*, Kodibagkar VD*, Siloxane nanoprobes for labeling and dual functional modality imaging of neural stem cells. Annals of Biomedical Engineering, 2015 44(3):816-827. PMID: 26597417
16. J X. Yin, G.H. Turner, S.W. Coons, M. Maalouf, E.M. Reiman, J. Shi, Association of amyloid burden, brain atrophy and memory deficits in aged Apolipoprotein ε4 Mice, Current Alzheimer Research, 2014, Mar, 11(3):283-90
17. J. Bell, Q.-W. Liu, Q. Zhao, Y. Gan, F.-D. Shi, G.H. Turner, Visualization of inflammation and demyelination in 2D2 transgenic mice with rodent MRI, J Neuroimmunol, 2013, Nov, 264(1-2):35-40
18. J.A. Kaufman, G.H. Turner, P.A. Holroyd, F. Rovero, A. Grossman, Brain Volume of the Newly-Discovered Species Rhynchocyon udzungwensis (Mammalia: Afrotheria: Macroscelidea): Implications for Encephalization in Sengis, PLOS ONE, 2013, 8(3):e58667
19. D.-Y. Kim, J. Hao, R. Liu, G.H. Turner, J.M. Rho, F.-D. Shi, Inflammation- Mediated Memory Dysfunction and Effects of Ketogenic Diet in a Murine Model of MS, PLOS ONE, 2012, 7(5): e35476
20. Q. Liu, Y. Cai, G.H. Turner, H. An, A Magnetic Resonance (MR) Compatible Selective Brain Temperature Manipulation System for Preclinical Study, Medical Devices: Evidence and Research, 2012, Mar, 2012(5):12-22
21. J.-X. Yin, G.H. Turner, H.-J, Lin, S.W. Coons, S.T. Marsh, J. Shi, Deficits in spatial learning and memory is associated with hippocampal volume loss in aged transgenic apoliopoprotein E4 mice, Journal of Alzheimer’s Disease, 2011, Nov, 27(1):89-98
22. J. Hao, A.R. Simard, G.H. Turner, J.Wu, P. Whiteaker, R.J. Lukas, F.-D. Shi, Attenuation of CNS Inflammatory responses by nicotine involves α-7 and non-α7 nicotinic receptors, Experimental Neurology, 2011, Jan, 227(1):110-119